基础医学与临床 ›› 2018, Vol. 38 ›› Issue (12): 1724-1726.

• 研究论文 • 上一篇    下一篇

两种提取油对胃溃疡小鼠的胃酸分泌水平及胃蛋白酶活性的影响比较

周志林1,梅勇2,戴军2,杨旭辉2,赵志辉2   

  1. 1. 华中科技大学同济医学院附属梨园医院普通外科
    2. 华中科技大学同济医学院附属梨园医院
  • 收稿日期:2018-01-15 修回日期:2018-03-30 出版日期:2018-12-05 发布日期:2018-11-23
  • 通讯作者: 周志林 E-mail:zhouzhilin468@163.com

Comparison of the effects of two kinds of extract oil on gastric acid secretion and pepsin activity in mice with gastric ulcer

  • Received:2018-01-15 Revised:2018-03-30 Online:2018-12-05 Published:2018-11-23

摘要: 目的 对比两种提取油对胃溃疡小鼠胃酸分泌水平及胃蛋白酶活性的影响,为治疗胃溃疡疾病提供实验依据。方法 120只昆明小鼠随机均分为对照组、模型组、黄秋葵种子油和姜油预防组。给药1周后,利用无水乙醇诱导法制备胃溃疡小鼠模型。检测计算各组小鼠胃液总酸度及胃蛋白酶活性。结果 模型组小鼠胃液总酸度及胃蛋白酶活性均高于对照组(P<0.05);黄秋葵种子油组和姜油组小鼠胃液总酸度及胃蛋白酶活性均低于对照组,且黄秋葵种子油组较姜油组低(P<0.05)。结论 黄秋葵种子油和姜油均对无水乙醇诱导型胃溃疡小鼠胃黏膜有保护作用,且同等剂量黄秋葵种子油的保护作用更显著。

关键词: 关键词:黄秋葵种子油, 姜油, 胃溃疡, 胃酸, 胃蛋白酶

Abstract: Objective To compare the effect of two kinds of extract oil on gastric acid secretion and pepsin activity in mice with gastric ulcer and provide experimental basis for the treatment of gastric ulcer disease. Methods One hundred and twenty KM mice were randomly divided into control group, model group, okra seed oil and ginger oil prevention group. The gastric ulcer mice model were induced by ethanol, which were then given drugs for one week. The total acidity of gastric juice and pepsin activity in each group were measured and calculated. Results The total acidity and pepsin activity of gastric juice in the model group were higher than that in the blank control group (P<0.05). The total acidity and pepsin activity of gastric juice in okra seed oil group and ginger oil group were lower than that in the control group; The total acidity and pepsin activity of gastric juice in okra seed oil group were lower than that in ginger oil group (P<0.05). Conclusions Okra seed oil and ginger oil have protective effect on gastric ulcer in mice gastric mucosa, and the protective effect of the same dosage of the seed oil of okra is more significant.

Key words: Key words: Okra Seed Oil, Ginger Oil, Gastric ulcer, Gastric acid, Pepsin