关键词: 脑胶质瘤, 侵袭性, 细胞间黏附分子-1/ICAM-1, 血管-细胞黏附分子-1/VCAM-1, 瘤周组织

Abstract: Objects To explore the relationship between ICAM-1, VCAM-1 and invasibility of glioma. Methods The peripheral, central part of glioma and the normal brain tissue were obtained from 44 specimens with glioma. The expression of ICAM-1 and VCAM-1 in these specimens was detected by immunohistochemistry (IHC), RT-PCR and Western blot. Results The difference between peripheral, central part of glioma and normal brain tissue is statistically significant(p<0.05). And the difference between two of these three groups was statistically significant(p<0.01) when the pairwise comparison of these three groups was done. The expression in tumor peripheral tissue is the highest, followed by the tumor central tissue, and the expression in normal brain tissue is the lowest. The result is the same as above when these specimens were grouped by pathological grade. Conclusions ICAM-1 and VCAM-1 have significant relation to invasibility of glioma.

Key words: glioma, invisibility, Intercellular adhesion molecular-1(ICAM-1), Vascular cell adhesion molecular-1(VCAM-1), tumor peripheral tissue.