基础医学与临床 ›› 2016, Vol. 36 ›› Issue (11): 1578-1581.

• 短篇综述 • 上一篇    下一篇

多胺的合成代谢与肿瘤治疗

吴红艳1,黄亚1,王艳林2   

  1. 1. 三峡大学医学院
    2. 三峡大学分子生物学研究所
  • 收稿日期:2015-12-21 修回日期:2016-03-25 出版日期:2016-11-05 发布日期:2016-10-24
  • 通讯作者: 王艳林 E-mail:fzswangyl@ctgu.edu.cn
  • 基金资助:
    AZ-AZIN作为抗肿瘤治疗分子靶点的实验研究

Polyamine anabolism and oncotherapy

  • Received:2015-12-21 Revised:2016-03-25 Online:2016-11-05 Published:2016-10-24

摘要: 多胺合成代谢关键酶鸟氨酸脱羧酶(ODC)和S-腺苷甲硫氨酸脱羧酶(AdoMetDC)与肿瘤的发生和转移密切相关。现有的ODC和AdoMetDC的抑制剂在临床实验中毒不良反应大或疗效不佳,将抑制剂和其他药物联用或通过计算机与实验相结合的方式开发小分子抑制剂有望为肿瘤治疗提供新的思路。

关键词: 多胺, 合成代谢, 肿瘤治疗, 鸟氨酸脱羧酶, S-腺苷甲硫氨酸脱羧酶

Abstract: Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are the key enzymes in the pathway of polyamine anabolism, they are closely related to the occurrence and metastasis of tumor. The effects of existing inhibitors are toxic or have poor effect in clinic trails, the inhibitor and other drugs combined together or development of small molecule inhibitors by coupling computational and experimental tools are expected to provide new ideas for tumor treatment.

Key words: polyamines, polyamine anabolism, tumor, ornithine decarboxylase, S-adenosylmethionine decarboxylase

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