基础医学与临床 ›› 2016, Vol. 36 ›› Issue (11): 1554-1557.

• 研究论文 • 上一篇    下一篇

2 499例肺炎克雷伯菌临床分布及耐药性分析

黄郁竹1,张冰琦1,杨忠贤2,陈涛2,丁宸2   

  1. 1. 南京中医药大学附属徐州中心医院
    2. 东南大学医学院 附属徐州医院
  • 收稿日期:2016-07-01 修回日期:2016-09-20 出版日期:2016-11-05 发布日期:2016-10-24
  • 通讯作者: 张冰琦 E-mail:2491827933@qq.com

Analyse of clinic distribution and antibiotic resistance of 2 499 isolates of Klebsiella pneumoniae

  • Received:2016-07-01 Revised:2016-09-20 Online:2016-11-05 Published:2016-10-24

摘要: 目的 分析肺炎克雷伯菌耐药性趋势,指导临床合理用药。方法 对医院2,499例临床送验标本分离出的肺炎克雷伯菌耐药性进行统计分析。结果 标本来源以痰液、尿液和血液居前3位,分别占比52.78%、12.28%、10.04%。肺炎克雷伯菌对青霉素类、头孢类抗菌药物耐药率较高>80%;对碳青霉烯类抗菌药物亚胺培南耐药率有增长趋势;对替甲环素和厄他培南均高度敏感。2,499例多重耐药的肺炎克雷伯菌检出率分别为24.45%,多重耐药的肺炎克雷伯菌检出率呈上升趋势。结论 针对肺炎克雷伯菌耐药性变迁,及时采取抗菌药物预警指导,合理使用抗菌药物,有效控制繁殖耐药菌产生,降低耐药率。

关键词: 肺炎克雷伯菌, 抗菌药物, 多重耐药

Abstract: Objective To investigate the trend of the clinic distribution and antibiotic resistance of Klebsiella pneumoniae,and to provide the reasonable clinical application scheme of antibiotics. Methods To analyse the antibiotic resistance of 2,499 isolates of klbsiella pneumoniae from clinical samples collected in our hospital during the period of 2013-2015.Results The Klebsiella pneumonia-positive specimens were mostly derived from sputum(52.7%), urine(12.28%), and blood(10.04%). The rates of resistance for cephalosporins and penicillins were above 80%. As for carbapenems,clinical isolates of Klebsiella pneumoniae have still displayed high degrees sensitivity for tigecycline and ertapenem, while the resistance rate for imipenem was incresing,The rates of multidrug resistance in 2,499 strains isolated in 2013- 2015 were 24.45% which was higher than before.Conclusion: Accordding to the changing of drug resistance of Klebsiella pneumoniae, for effectively to control the production of resistant bacteria and reduce the rate of drug resistance,we take augnt to the early warning guidance of antimicrobial agents in time and using of antibiotics rationally.

Key words: Klebsiella pneumoniae, Antimicrobial agents, Multiple resistance