SWI/SNF染色质重塑在肿瘤中的研究进展

基础医学与临床 ›› 2016, Vol. 36 ›› Issue (10): 1437-1440.

SWI/SNF染色质重塑在肿瘤中的研究进展

张记¹,吴玉章²,阎萍³

1. 第三军医大学全军免疫学研究所
2. 第三军医大学
3. 第三军医大学西南医院妇产科

收稿日期:2015-10-22 修回日期:2015-12-30 出版日期:2016-10-05 发布日期:2016-09-27
通讯作者: 阎萍 E-mail:yp2312853@163.com
基金资助:
教育部肿瘤免疫病理学重点实验室开放课题;长江学者和创新团队发展计划

Research progress of SWI/SNF chromatin remodeling in malignancies

Received:2015-10-22 Revised:2015-12-30 Online:2016-10-05 Published:2016-09-27

摘要/Abstract

摘要： 染色质重塑复合体SWI/SNF亚基基因在肿瘤中突变率高达约20%，突变造成编码蛋白失活及整个复合体功能异常，导致肿瘤发生。目前SWI/SNF抑制肿瘤的已知机制主要包括其与Polycomb复合体间的表观拮抗及与c-Myc及PIK3CA等致癌基因信号通路协同作用等。

关键词: 关键词: SWI/SNF, 染色质重塑, ARID1A

Abstract: The mutations of SWI/SNF subunits genes, with about 20% high in human cancers, promote oncogenesis by inactivating the function of encoding proteins and further perturbing the whole function of SWI/SNF complexes. The main yet known mechanisms by which SWI/SNF suppress tumor development include its epigenetic antagonism with Polycomb complexes, as well as synergetic interaction with other oncogene signaling such as c-Myc and PIK3CA.

Key words: Key words: SWI/SNF, chromatin remodeling, ARID1A

中图分类号:

R730.2

张记吴玉章阎萍. SWI/SNF染色质重塑在肿瘤中的研究进展[J]. 基础医学与临床, 2016, 36(10): 1437-1440.