关键词: 哺乳动物雷帕霉素靶蛋白, 糖代谢, 脂代谢, 转录因子

Abstract: The mammalian target of rapamycin(mTOR) is an important signal molecule in a variety of physiological mechanisms, including protein synthesis, cell proliferation, cell cycle, energy metabolism, autophagy, etc. It is increasingly apparent that mTOR deregulation occurs in cancer and metabolism disorders. The transcription factors of downstream of mTOR such as HIF1α, c-Myc, FoxO1, SREBPs, PPARγ/PPARα and TFEB play key roles in regulating the metabolism of glucose and lipid.

Key words: mTOR, glucose metabolism, lipid metabolism, transcription factor