关键词: 胶原和钙结合EGF 域1, 血管内皮生长因子-C, 淋巴管生成, 预后, 喉癌

Abstract: Objective To investigate the expression of Ccbe1 in patients with laryngeal cancer, and the relationship with vascular endothelial growth factor C, lymphangiogenesis and their prognosis significance. Methods Forty five specimens of the laryngeal cancer and twenty benign laryngeal diseases were studied．The protein expression of Ccbe1 and VEGF-C were observed by immunohistochemistry and Western bolt. LVD was evaluated by LYVE-1 staining, and then judged the role of Ccbe1 in laryngeal cancer prognosis by using Kaplan-meier method. Results The protein expression of Ccbe1 and VEGF-C were much higher in tumor tissue than in the normal tissue（P＜0.05）, and the expression of Ccbe1 was significantly correlated with VEGF-C（r=0.338，P＜0.05）.The expression of Ccbe1 was significantly correlated with LVD, TNM stage and lymph node metastasis（P＜0.05）,and the expression of VEGF-D was significantly correlated with LVD and lymph node metastasis（P＜0.05）.The different expression of Ccbe1 had effect on survival ratio（P＜0.05）.Conclusion Ccbe1 stimulates VEGF-C upregulation and promote lymphangiogenesis in laryngeal cancer. Detection of Ccbe1 protein may be helpful for judging prognosis in laryngeal cancer.

Key words: Ccbe1, VEGF-C, lymphangiogenesis, prognosis, laryngeal cancer