关键词: 血管紧张素转换酶, 醛固酮合成酶, α-内收蛋白, 基因多态性, 原发性高血压

Abstract: Objective The aim was to investigate the association between ACE, CYP11B2 and α-ADDUCIN gene polymorphisms and primary hypertensive subjects. Methods A total of 1380 essential hypertension and 888 normal controls were surveyed in Fujian Chinese population. The genotype for ACE、CYP11B2 and α-ADDUCIN were determined by polymerase chain reaction (PCR)and restriction fragment length polymorphism (RFLP). Results In multigene analysis，the frequencies of ACE-DD +ADDUCIN-TT genotype and ACE-DD + CYP11B2-TC/CC genotype were significantly higher in hypertension group than control group(P< 0.05)，OR(95% CI)were 1.81(1.09, 3.01)(P< 0.05) and 1.61(1.15,2.27)(P <0.01)respectively;the frequencies of ACE-DD+CYP11B2-TC/CC +ADDUCIN-TT genotype was significantly higher in hyperten- sion group than control group(P< 0.05)，OR(95% CI) was 2.82 (1.41-5.65),(P<0.01). Conclusion The combined genotype ACE-DD、ADDUCIN-TT and CYP11B2-TC/CC might be related with hypertension.It was possible that multigenes were interacted in the etiology of hypertension.

Key words: angiotensin converting enzyme (ACE) , aldosterone synthase (CYP11B2) , α-adducin, gene polymorphism , primary hypertension