被动胃切除术对2型糖尿病患者血糖的影响

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (5): 570-573.

被动胃切除术对2型糖尿病患者血糖的影响

李曾一¹,李玉秀²,康维明¹,李伟³,于健春⁴,王守俊⁵,闵锐

收稿日期:2012-02-28 修回日期:2012-03-22 出版日期:2012-05-05 发布日期:2012-04-16
通讯作者: 李玉秀 E-mail:liyuxiu@medmail.com.cn

The influence on glycemia control for type 2 diabetes patients underwent the bariatric surgery passively

Received:2012-02-28 Revised:2012-03-22 Online:2012-05-05 Published:2012-04-16
Contact: Yu-xiu LI, E-mail:liyuxiu@medmail.com.cn

摘要/Abstract

摘要： 目的本研究通过对被动接受胃切除术的2型糖尿病患者术前资料进行分析，以探讨影响2型糖尿病胃部切除手术后血糖转归的相关因素，为今后此种治疗方法的病人选择提供参考。方法回顾分析2001年1月至2010年12月在北京协和医院行胃部切除手术的2型糖尿病患者的临床资料，纳入45例，以术后血糖或抗糖尿病药物用量降低20%为缓解标准，分为缓解组（29例）和无效组（16例），比较两组年龄、体重指数(BMI)、病程、术前血压等因素之间的差异。结果 2型糖尿病病程缓解组为5.51±1.70年，无效组为10.70±2.31年，差异具有统计学意义。缓解组和无效组的平均年龄分别为61.43±11.33岁和 67.09±9.10岁，BMI为23.19±2.28 kg/m2和25.24±3.40 kg/m2，无显著改变。术前兼有高血压者胃部手术对其血压的影响亦无明显变化。结论胃部手术治疗2型糖尿病宜选择病程较短（5年以下）者。本研究是被动接受胃部手术的回顾性分析，结果尚需大样本前瞻性研究进行证实。

关键词: 胃切除术 2型糖尿病

Abstract: Objective: The patients with T2DM that passively underwent gastrectomy were chosen and the differences of their basic clinical data before and after the gastrectomy were analyzed to find the contribution of the factors in glycemia control. Thus the information of bariatric surgery in treating T2DM was offered in our country. Methods: The clinical data of 45 patients with T2DM that underwent gastrectomy in Peking Union Medical College Hospital from January 2001 to December 2010 have been retrospectively analyzed in this study. The patients were divided into the improved group (29 cases) and the ineffective group (16 cases) with the standard that whether the glucose level or amount of antidiabetic drug reduced for 20% after surgery or not. The data of age, body mass index(BMI), course of T2DM,preoperative blood pressure were analyzed to determine the influencing factors of the differences between the improved group and the ineffective group. Results: There was a significant difference in the course of T2DM between the improved group(5.51±1.70)and ineffective group(10.70±2.31).In the improved group and ineffective group, the average age was 61.43±11.33 and 67.09±9.10, BMI was 23.19±2.28 and 25.24±3.40 respectively. The differences were both not statistically significant. In addition, the blood pressure didn’t have significant change after the surgery in patients with both T2DM and hypertension. Conclusion: The surgical treatment of T2DM is suitable for patients with shorter courses of T2DM(less than 5 years). BMI is meaningless in choosing the patients. The sample size of this study was small and the gastrectomy was passive in the patients thus prospective studies with large samples are needed to verify this conclusion.

Key words: gastrectomy, T2DM

中图分类号:

R656.6+1 R587.1

李曾一李玉秀康维明李伟于健春王守俊闵锐. 被动胃切除术对2型糖尿病患者血糖的影响[J]. 基础医学与临床, 2012, 32(5): 570-573.