Abstract: OBJECTIVE: To analyze Genotype-phenotype correlations in APC gene and Familial adenomatous polyposis (FAP) of Chinese .METHODS:APC gene germline mutation was detected in 14 FAP families . The correlations between APC gene mutations type and clinical features were synthetically analyzed. RESULTS: The patients whose mutaions were identified at codon 443,779,1062,1068,1308,1309,1394, c.657+1 and c.532-2 manifested profuse polyposis, and the patients whose large fragment deletions were detected manifested intermediate polyposis, and three patients who had not mutation or large fragment deletion detected and two of them presented intermediate polyposis and one attenuated polyposis. CONCLUSION: The range of APC gene germline mutation site in Chinese profuse polyposis wider than Western countries which report is in codon 1250~1464.