FOXC1在消化系统癌发生发展中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.07.1049

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (7): 1049-1053.doi: 10.16352/j.issn.1001-6325.2024.07.1049

FOXC1在消化系统癌发生发展中作用的研究进展

金庆¹, 丁佑铭^2*

1.武汉大学第一临床学院,武汉 430000;
2.湖北省人民医院肝胆外科,武汉 430000

收稿日期:2023-11-09 修回日期:2024-01-24 出版日期:2024-07-05 发布日期:2024-06-26
通讯作者: ^*dingym@whu.edu.cn

Research progress on the role of FOXC1 in the development of digestive system cancer

JIN Qing¹, DING Youming^2*

1. The First Clinical College of Wuhan University, Wuhan 430000;
2. Department of Hepatobiliary Surgery, Hubei People's Hospital, Wuhan 430000, China

Received:2023-11-09 Revised:2024-01-24 Online:2024-07-05 Published:2024-06-26
Contact: ^*dingym@whu.edu.cn

摘要/Abstract

摘要： 叉头盒蛋白C1(FOXC1)是一个癌相关的转录因子,在癌发生发展相关的各种信号通路中发挥着重要作用。FOXC1从多个方面参与调控癌细胞,包括增殖、转移、复发等。FOXC1可通过上调癌基因的表达,如细胞周期蛋白D1,促进细胞周期的进展和细胞增殖。FOXC1可促进上皮细胞-间质转化(EMT),在EMT过程中,细胞从极化的上皮细胞转变为具有间质特征的细胞,这有助于肿瘤细胞的浸润和迁移。FOXC1可通过调控与血管生成相关的基因在肿瘤血管生成中发挥作用。FOXCI可通过调控活性氧水平、激活β-catenin的表达等方式增强细胞迁移与侵袭。总之,FOXC1通过多种机制发挥其功能。

关键词: FOX家族, 叉头盒蛋白C1, 消化系统癌, 信号通路

Abstract: forkhead box protein C1(FOXC1) is a cancer-related transcription factor that plays an important role in various signaling pathways related to cancer development.FOXC1 is involved in the regulation of cancer cells from many aspects, including proliferation, metastasis and recurrence.FOXC1 can promote cell cycle progression and cell proliferation by up-regulating the expression of oncogenes, such as cyclin D1.FOXC1 promotes epithelial-mesenchymal transition (EMT), in which cells change from polarized epithelial cells to cells with stromal characteristics, which contributes to tumor cell infiltration and migration.FOXC1 may play a role in tumor angiogenesis by regulating genes associated with angiogenesis.FOXCI can enhance cell migration and invasion by regulating reactive oxygen species and activating β-catenin expression.In summary, FOXC1 functions through a variety of mechanisms.

Key words: the FOX family, FOXC1, digestive system cancers, signal pathway

中图分类号:

R735

金庆, 丁佑铭. FOXC1在消化系统癌发生发展中作用的研究进展[J]. 基础医学与临床, 2024, 44(7): 1049-1053.

JIN Qing, DING Youming. Research progress on the role of FOXC1 in the development of digestive system cancer[J]. Basic & Clinical Medicine, 2024, 44(7): 1049-1053.

参考文献

[1]Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021,71:209-249.
[2]Weigel D, Jürgens G, Küttner F, et al.The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo[J].Cell,1989, 57:645-658.
[3]Berry FB, Saleem RA, Walter MA. FOXC1 transcrip-tional regulation is mediated by N-and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain[J].Biol Chem,2002,277:10292-10297.
[4]Lin Z, Huang W, He Q, et al.FOXC1 promotes HCC proliferation and metastasis by upregulating DNMT3B to induce DNA hypermethylation of CTH promoter[J].J Exp Clin Cancer Res,2021,40:50. doi: 10.1186/s13046-021-01829-6.
[5]侯丽杰,马承旭,王晶宇,等.LncRNA(HOTAIR)/miR-206/TAGLN2信号轴调控甲状腺乳头状癌细胞的侵袭[J].基础医学与临床,2023,43:1642-1647.doi:10.16352/j.issn.1001-6325.2023.11.1642.
[6]周堤侠,吕海栋.长链非编码RNA MCM3AP-AS1靶向调控miR-876-5p促进人结直肠癌细胞系的增殖和迁移[J].基础医学与临床,2021,41:225-232.doi:10.16352/j.issn.1001-6325.2021.02.015.
[7]Wu SM, Chen J, Liang Y, et al.Long non-coding RNA ZEB2-AS1 promotes hepatocellular carcinoma progression by regulating the miR-582-5p/FOXC1 axis[J]. Cell J,2022,24:285-293.
[8]Yang G, Guo S, Liu HT, et al. miR-138-5p predicts negative prognosis and exhibits suppressive activities in hepatocellular carcinoma HCC by targeting FOXC1[J]. Eur Rev Med Pharmacol Sci,2020,24:8788-8800.
[9]Li D, Zhang Y, Li Y, et al. miR-149 suppresses the proliferation and metastasis of human gastric cancer cells by targeting FOXC1[J]. Biomed Res Int,2021,2021:1503403. doi: 10.1155/2021/1503403.
[10]Sun Y, Lin C, Ding Q, et al. Overexpression of FOXC1 promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in gastric cancer[J].Dig Dis Sci, 2022,67:3742-3752.
[11]Eizuka M, Osakabe M, Sato A, et al.Dysregulation of microRNA expression during the progression of colorectal tumors[J]. Pathol Int,2020,70:633-643.
[12]Khan P, Siddiqui JA, Kshirsagar PG, et al. MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis[J]. Mol Cancer,2023,22:1.doi: 10.1186/s12943-022-01695-6.
[13]Garo LP, Ajay AK, Fujiwara M, et al.MicroRNA-146a limits tumorigenic inflammation in colorectal cancer[J]. Nat Commun,2021,12:2419.doi: 10.1038/s41467-021-22641-y.
[14]Liu M, Zhang Y, Yang J, et al.Zinc-dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer[J]. Gastroenterology,2021,160:1771-1783.
[15]Motoo I, Nanjo S, Ando T, et al.Methylation silencing of ULK2 via epithelial-mesenchymal transition causes transformation to poorly differentiated gastric cancers[J]. Gastric Cancer,2022,25:325-335.
[16]Jiang J, Li J, Yao W, et al. FOXC1 negatively regulates DKK1 expression to promote gastric cancer cell prolifera-tion through activation of Wnt signaling pathway[J]. Front Cell Dev Biol,2021,9:662624. doi: 10.3389/fcell.2021.662624.
[17]Guo Q, Xu J, Huang Z, et al. ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway[J]. Clin Transl Oncol,2021,23:325-334.
[18]Alvarado-Ortiz E, Ortiz-Sánchez E, Sarabia-Sánchez MA, et al.Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer[J]. J Cell Commun Signal,2023,17:1389-1403.
[19]Wang J, Li S, Liu Y, et al.Metastatic patterns and survival outcomes in patients with stage Ⅳ colon cancer: a population-based analysis[J]. Cancer Med,2020,9:361-373.
[20]Gao M, Huang J, Jiang X, et al.Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters[J]. Protein Cell, 2020,11:446-451.
[21]Zheng X, Fan H, Liu Y, et al.Hypoxia boosts aerobic glycolysis in carcinoma: a complex process for tumour development[J].Curr Mol Pharmacol,2022,15:487-501.
[22]Liu Z, Chen M, Xu X, et al.USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1[J]. Acta Biochim Pol,2021,68:633-639.
[23]Li Q, Wei P, Wu J, et al.The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect[J]. Oncogene,2019,38:483-496.
[24]Aravalli RN, Greten TF. FoxC1: novel regulator of inflammation-induced metastasis in hepatocellular carcinoma[J]. Gastroenterology,2015,149:861-873.
[25]Subramani R, Camacho FA, Levin CI, et al.FOXC1 plays a crucial role in the growth of pancreatic cancer[J]. Oncogenesis,2018,7:52. doi: 10.1038/s41389-018-0061-7.

FOXC1在消化系统癌发生发展中作用的研究进展

Research progress on the role of FOXC1 in the development of digestive system cancer

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