Research progress on the difference of atherosclerosis between different sexes

doi:10.3969/j.issn.1672-6731.2023.09.016

Abstract

Abstract:

Cardiovascular and cerebrovascular diseases are the main causes of disability and death, and atherosclerosis is an important cause. The incidence of atherosclerosis in premenopausal women is significantly lower than that in men of the same age, while the incidence of atherosclerosis in postmenopausal women is significantly higher than that in men of the same age, which is closely related to estrogen levels. In this paper, sex differences in atherosclerosis were reviewed from the aspects of imaging examination, risk factors, intestinal microbiome and vascular inflammatory effects on atherosclerosis, to provide evidence for precision medical treatment of atherosclerosis.

Key words: Atherosclerosis, Sex factors, Magnetic resonance imaging, Risk factors, Gastrointestinal microbiome, Inflammation, Review

摘要：

心脑血管病是病残和病死的主要原因，动脉粥样硬化是其重要病因。绝经前女性动脉粥样硬化发生率明显低于同龄男性，而绝经后女性动脉粥样硬化发生率显著升高甚至超过同龄男性，与雌激素水平密切相关。本文从影像学检查、危险因素、肠道微生物群和血管炎症反应对动脉粥样硬化影响等方面综述动脉粥样硬化的性别差异，为动脉粥样硬化的精准医疗提供依据。

关键词: 动脉粥样硬化, 性别因素, 磁共振成像, 危险因素, 胃肠道微生物组, 炎症, 综述

Ya-wei WANG, Feng TIAN. Research progress on the difference of atherosclerosis between different sexes[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(9): 864-871.

王亚伟, 田锋. 不同性别动脉粥样硬化差异性研究进展[J]. 中国现代神经疾病杂志, 2023, 23(9): 864-871.

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