摘要： 目的 探讨中国老年人血清半胱氨酸蛋白酶抑制剂C（以下简称胱抑素C）是否为运动认知风险综合征（MCR）潜在危险因素。方法 纳入来源于如皋长寿和衰老研究队列子队列2019年随访时的1592名老年人，采用简版老年抑郁量表评估是否存在主观认知抱怨，5米步行速度测验评估是否存在步速缓慢，二者同时存在判定为运动认知风险综合征（MCR组，132例）。根据血清胱抑素C水平将胱抑素C < 1.06 mg/L者归为低胱抑素C组（794例），≥ 1.06 mg/L者归为中高胱抑素C组（798例）。采用单因素及多因素逐步法Logistic回归分析判断血清胱抑素C水平升高是否增加运动认知风险综合征的风险。结果 与无MCR组相比，MCR组年龄较大（P=0.041），女性（P=0.027）、农民（P=0.044）、在婚（P=0.034）、脑血管病（P=0.015）比例较高，胱抑素C水平较高（P=0.023）。与低胱抑素C组相比，中高胱抑素C组年龄较大（P=0.000），男性（P=0.000）、高血压（P=0.006）、运动认知风险综合征（P=0.049）比例较高，农民比例较低（P=0.001），吸烟状况组间差异亦具有统计学意义（P=0.041）。Logistic回归分析显示，血清胱抑素C水平升高是运动认知风险综合征的独立危险因素（OR=1.419，95% CI：1.027~1.962； P=0.034）。结论 年龄较大、女性、务农及有脑血管病病史的老年人运动认知风险综合征发病率较高，且胱抑素C水平升高是潜在危险因素。

关键词: 认知障碍, 半胱氨酸蛋白酶抑制物C, 危险因素, Logistic模型, 老年人

Abstract: Objective To investigate whether serum cystatin C motoric cognitive risk syndrome (MCR) in Chinese elderly. Methods A total of 1592 elderly people were included in the subcohort from Rugao Longevity and Aging Study (RuLAS) at the third follow-up in 2019. The presence of subjective memory complaints was assessed by Geriatric Depression Scale (GDS-15) and the presence of slow walking speed was assessed by the 5-Meter Walking Speed Test. The presence of both symptoms was determined as MCR (n=132). According to the serum Cys C level, the patients with serum Cys C level < 1.06 mg/L were classified as low level group (n=794), and the patients with serum Cys C level ≥ 1.06 mg/L were classified as middle and high level group (n=798). Univariate and multivariate stepwise Logistic regression were used to analyze whether elevated serum Cys C levels increased the risk of MCR. Results Compared with non-MCR group, MCR group had higher age (P=0.041), female proportion (P=0.027), farmer occupation (P=0.044), married status (P=0.034), cerebral vascular disease (P=0.015), higher Cys C level (P=0.023). Compared with the Cys C low level group, the Cys C middle and high level group had higher age (P=0.000), male (P=0.000), hypertension (P=0.006), MCR (P=0.049), and lower farmer proportion (P=0.001); there was significant difference in smoking status (P=0.041). Logistic regression analysis showed that increased Cys C level was a risk factor for the occurrence of MCR (OR=1.419, 95%CI:1.027-1.962; P=0.034). Conclusions The incidence of MCR is higher in older people, female, farmers and the elderly with the history of cerebral vascular disease, and increased Cys C level is a potential risk factor for MCR.

Key words: Cognition disorders, Cystatin C, Risk factors, Logistic models, Aged