Abstract: Objective To explore the effect of different treatment and different response on the prognosis of small cell lung cancer. Method Collect patients diagnosed as small cell lung cancer and admitted to our department to receive chemotherapy between Jan 2002 to Jan 2010, review their records and do follow-up. Analyze the potential variables and only factors associated with survival with a P value less than o.1 in univariate analysis were introduced into the Cox regression model. Results 76 cases were included in this study. For local stage, 1-year,2-year, and 5-year survival rate are 81%,56%,21%,respectively. For extend stage,1-year,2-year survival rate are 59%,24%. Chemotherapy combined with radiotherapy, CR+PR obtained in first-line chemotherapy are associated with survival. For local stage, complete resection is associate with survival. In Cox regression, the variables above are all independent factors of survival. Conclusion Chemotherapy combined with radiotherapy, increasing the effectiveness of first-line regimen, and complete resection for selected local stage patient may be the way to improve survival of small cell lung cancer patients.