Abstract: Chemotherapy plays an important role in advanced colorectal cancer.patient may acquire various clinical response by selection different drugs .the importance of individual therapy which based on Pharmacogenomics has been emphasized in cancer therapy. To explore the individual therapy of colorectal cancer ,the progress of molecular markers which influence the efficacy of anti-tumor drugs containing Fluorouracil,Oxaliplatin,CPT-11, Monoclonal antibody drugs is reviewed in this article.