Abstract: Objective To explore the relationship of acute myeloid leukemia kayotype with chemotherapeutic effect. Methods Conventional cytogenetic technique of G-band was used to analyze in 222 acute myeloid leukemia patients. Results　 Eighty-six cases(42.1%) with cytogenetic abnormalities were found in 204 patients.Excepting for M3 patients ,the favorable,intermediate and adverse groups according for MRC criteria were treated with TA or CAG schema respectively.The CR rate of M3 was obviously higher than non-M3.The favorable and intermediate group were obviously surpassinger than adverse group in TA schema.The CR rate of the intermediate group was highter than that of the other groups in CAG schema.The CR rate of the adverse group in two schema were all low.The CAG was surpassinger than TA schema in intermediate group. Conclusions Cytogenetics is an important chemotherapeutic and prognostic factor to acute myeloid leukemia. CAG schema could be the leader selection in the de novo presby or oligoaccrementional AML patients.

Key words: karyotyping, acute myeloid leukemia, chemotherapeutic effect