Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (10): 1100-1104.

• 短篇综述 • Previous Articles     Next Articles

Microglia-derived IL-1 exacerbating the progress of Parkisinson's disease

Jing-jing WU, Biao CHEN   

  1. Xuanwu Hospital, Capital Medical University Xuanwu Hospital, Capital Medical University
  • Received:2009-10-26 Revised:2010-01-07 Online:2010-10-05 Published:2010-10-05
  • Contact: Biao CHEN

Abstract: Parkinson's disease (PD) is a common neurodegenerative disease in the central neural system. Genetic and environmental factors induce microglia secrete more interleukin-1, which will cause dopaminergic neurons death through several mechanisms, such as promoting the synthesis of other pro-inflammatory cytokines, producing free radicals, increasing the intracellular calcium concentration, and inducing elevation of α-synuclein , and so on. It is a potential therapeutic target for Parkinson's disease.

Key words: interleukin-1, Parkinson’s disease, pathogenesis