Abstract: Objective To study the expression pattern of RYK in the pathway of developmental corticospinal tract projection and provide hints for further study on RYK's function involved in this processes. Method By In situ and immuno- fluorescence histochemistry, we thoroughly checked the RYK expression pattern in the developmental mice motor cortex and the projection of corticospinal tract at various time points of E14.5、 E16 、E18.5 and postnatal P3、 P5、P7. Results We found in the motor cortex the RYK expression started at E18.5 stage and enhanced gradually at P0 stage. Moreover from P0 to P5 stage the RYK expression also appeared in the pathway of developmental corticospinal tract and decreased gradually after that. Conclusion RYK's expression is closely related to the corticospinal tract projection during the development stage.

Key words: Corticospinal Tract, Ryk, Expression, Projection