Aquaporins and cancer

Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (12): 1334-1336.

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Aquaporins and cancer

Hong ZHANG, Zhen-zhen LI, Zhi-yong WANG, Jian-guo WEN

the First Affiliated Hospital of Zhengzhou University

Received:2009-03-03 Revised:2009-04-02 Online:2009-12-20 Published:2009-12-20
Contact: Hong ZHANG,

Abstract

Abstract: The aquaporins (AQPs) are small, integral-membrane proteins that selectively transport water across cell plasma membranes. AQPs are strongly expressed in tumor cells of different origins, particularly aggressive tumors. AQPs-expressing cancer cells show enhanced migration in vitro and greater local tumor invasion, tumor cell extravasations, and metastases in vivo. AQPs inhibition will provide a help for titumor therapy.

Key words: Angiogenesis, Aquaglyceroporin, Cell migration, Cell motility, Cell proliferation, Water channel

CLC Number:

R735.1

Hong ZHANG; Zhen-zhen LI; Zhi-yong WANG; Jian-guo WEN. Aquaporins and cancer[J]. Basic & Clinical Medicine, 2009, 29(12): 1334-1336.

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Aquaporins and cancer

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