Abstract: Objective To explore the effect of Angiopoietin-2(ANG-2) and Endostatin (ENS) in genesis and development of endometriosis.Methods 25 endometriosis cases were enrolled into present study.24 patients without endometriosis were selected control. ANG-2 and ENS in endometrium were detected by Immunohistochemistry. The concentrations of ANG-2 and ENS in peritoneal fluid were determinated with enzyme linked immunoabsorbant assay.Results In the EMs group ,the ANG-2 positive rate in eutopic endometrium was significantly higher than that of ectopic endometrium . The ANG-2 positive rate in ectopic endometrium was significantly higher than that of control group；In EMs group, The ENS positive rate in ectopic endometrium was significantly higher than that of eutopic endometrium .The ENS positive rate in eutopic endometrium was significantly higher than that of control group. There was no significant difference of ANG-2 or ENS between stageⅠ～Ⅱand stage Ⅲ～Ⅳ. In peritoneal fluid, ANG-2 and ENS concentration and ratio of ANG-2/ENS in endometriosis were significantly higher than that in controls. Conclusion The effect of angiopoietin-2 and endostatin in angiogenesis of endometriosis are important and adjust to pathogenesis and development of the endometriosis .

Key words: ngiopoietin-2, Endostatin, endometriosis, ngiopoietin-2, Endostatin, endometriosis, peritoneal fluid, serum