Abstract: Objective To discuss whether CX3CR1 V249I and T280M are associated with CAD. Methods Database in English and Chinese, including PUBMED, EMbase, were searched to get the case-control studies on the association between V249I, T280M and CAD. Results Six studies were enrolled. The pooled OR of V249I compared to wild type allele was OR=0.85（95%CI=0.67~1.08，P>0.05）. The pooled OR of T280M compared to wild type allele was OR=0.82（95%CI=0.70~0.96，P<0.05）. Conclusion The T280M is a protective factor of CAD, while the V249I is not associated with CAD.

Key words: Coronary artery disease, Polymorphism, CX3CR1, Meta-analysis