Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease

Basic & Clinical Medicine ›› 2008, Vol. 28 ›› Issue (12): 1336-1338.

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Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease

Guang YANG, Yuan-gang ZHU, Hui YANG

the Second Central Hospital of Jilin Beijing Institute for Neuroscience and Beijing Center for Neural Regeneration and Repairing, Capital Medical University Beijing Institute for Neuroscience and Beijing Center for Neural Regeneration and Repairing, Capital Medical University

Received:2008-06-17 Revised:2008-09-12 Online:2008-12-25 Published:2008-12-25
Contact: Hui YANG

Abstract

Abstract: Autophagy contributes to the pathology of various neurodegenerative conditions. Rapamycin, an agent against Candida albicans or immunosuppressive, was found to be effective against tumor. Furthermore, it also induces autophagy by inactivating the protein mammalian target of rapamycin (mTOR), FKBP and VMP1, thus could offer a tractable therapeutic agent for neurodegenerative diseases.

Key words: autophagy, rapamycin, neurodegenerative disease, therapeutic agent

Guang YANG; Yuan-gang ZHU; Hui YANG. Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease[J]. Basic & Clinical Medicine, 2008, 28(12): 1336-1338.

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Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease

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