Abstract: Objective To investigate the impact of propofol and midazolam on the time course of extubation in patients with mechanical ventilation. Methods The patients were randomly divided into the propofol group（n=37） and the midazolam group（n=52）, which were also attributed to three sedation stratums. The two drugs were discontinued immediately while weaning from the ventilator. The awakening time and extubation time of the two groups were recorded and compared with each other. Results Both awakening time and extubation time of the propofol groupswere shorter than those of the midazolam group（P＜0.05）.Conclusions After being used to sedate the patients with mechanical ventilation, the effect of propofol on reducing the time course of weaning was superior than that of midazolam.