Abstract: Objective To identify the distribution and function of glucocoiticoid receptor (GR) regulated target genes in the human genome, and to know the bioinformatic significance of it. Methods: With bioinformatics methods, we found out all the genes that contains Glucocorticoid Response Element's (GRE) consensus sequences, and extend our study to the distribution of consensus sequences in the human genome and the functions , protein products and the Gene Ontology (GO) number of the GR target genes and then to emphasize these genes' function in inflammation and immunity. Results: We found 225 genes which contain the GRE-1 consensus sequence (5'-AGAACAnnnTGTTCT-3') and 94 genes contain GRE-2 consensus sequence (5'-GGTACAnnnTGTTCT-3'). Conclusion: According to the analysis of the function of genes which contain the consensus sequence of GRE, F2R, DAXX, PAG1, ULBP3, OR8D4, RIMS1, NPY2R are correlate with inflammation and immunity.

Key words: Glucocorticoid, Glucocorticoid Receptor, Glucocorticoid Response Element, Consensus sequence of GRE, bioinformatics