Abstract: Objective To assess the changes of body composition with acromegaly before and after pituitary adenoma surgery, and the relationship between these changes and serum growth hormone(GH), insulin-like growth factor-1(IGF-1). Methods Serum GH with OGTT, IGF-1 levels, BMI, Fat%, FFM and total body water(TBW) in patients were measured in activity and relieved period of the disease. Results The BMI and FFM with active acromegalic males were significantly higher, but Fat% was significantly lower than those of healthy males . After the disease was relieved by surgery, serum GH, IGF-1 concentrations of patients were reduced significantly to normal level, but their BMI were still significantly higher, the Fat% increased and the FFM decreased was correlated with serum nadin GH and IGF-1 levels. The BMI and FFM with active acromegalic females were significantly higher than healthy females, but the Fat% had not significant change after surgery, and FFM decreased was correlated with reduced serum GH level. The Fat% did not change significantly. Conclusions There were significantly changes of body composition with acromagely before and after treatment, and were relationship between these changes and serum GH, IGF-1 levels

Key words: Acromegaly, Body composition, Fat percentage, Like insulin growth fector-1