Abstract: Objective To explore the outcomes of progesterone therapy for vary degrees of endometrial atypical hyperplasia, and the dose of progestin for vary degrees of endometrial atypical hyperplasia. Methods Twenty-five patients with endometrial atypical hyperplasia were treated with high dose of progestin from Jan 2002 to Jun 2006. The effect of treatment and the dose of progestin for vary degrees of endometrial atypical hyperplasia were analyzed respectively. Results 1. Nineteen cases achieved regressions after treated for 3～36 months；Four was partial remission ； Tow had persistent lesions.2. The range of dose of progestin for the mild and moderate endometrial atypical hyperplasia was 125～250 mg/d ,and the rate of complete remission was 87.5%(7/8)and 66.7%(6/9)，and the remission time was from 15 to 3 month with increasing dose of progesterone.The range of dosage of progestin for the severe was 250～500 mg/d and the rate was 75%(6/8). Conclusions For progesterone treatment of vary degrees of endometrial atypical hyperplasia, with increasing dose of progesterone ,its efficiency and remission rates increased and the remission time minimized.

Key words: endometrial hyperplasia, conservative treatment, progesterone