Abstract: Focal adhesion kinase(FAK), the non-receptor tyrosine kinase, has been implicated in regulating a number of fundamental biological signal transudation pathways that control cell proliferation, survival, adhesion, motility. Many researches had reported that FAK highly expresses in many cancers and involves in the developing of the cancer, such as initial, progress, metastasis, multi-drug resistance of cancer. FAK has been the hotpot in cancer research, and it will be a new target in cancer therapy.