[1]Schalkwijk CG, Stehouwer CDA. Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases[J]. Physiol Rev, 2020, 100: 407-461. [2]Stratmann B. Dicarbonyl stress in diabetic vascular disease[J]. Int J Mol Sci, 2022, 23:6186-6200. [3]Rabbani N, Thornalley PJ. Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples[J]. Nat Protoc, 2014, 9: 1969-1979. [4]Schalkwijk CG, Micali LR, Wouters K. Advanced glyca-tion endproducts in diabetes-related macrovascular complications: focus on methylglyoxal[J]. Trends Endocrinol Metab, 2023, 34: 49-60. [5]胡丽叶,宋光耀,朱旅云,等. 罗格列酮减轻2型糖尿病大鼠血管内皮功能受损[J]. 基础医学与临床, 2017, 37: 1585-1589. [6]成永霞,刘贵波,郭素芬,等. AGEs诱发大鼠心脏微血管内皮细胞iNOS表达[J]. 基础医学与临床, 2010, 30: 515-519. [7]Wang G, Wang Y, Yang Q, et al. Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo[J]. Cell Death Dis, 2022, 13: 29-40. [8]Rabbani N. Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes[J]. Clin Sci (Lond), 2022, 136: 819-824. [9]Kim D, Kim K A, Kim JH, et al. Methylglyoxal-induced dysfunction in brain endothelial cells via the suppression of Akt/HIF-1α pathway and activation of mitophagy associated with increased reactive oxygen species[J]. Antioxidants (Basel), 2020, 9:820-836. [10]Yuan J, Zhu C, Hong Y, et al. The role of cPLA2 in methylglyoxal-induced cell apoptosis of HUVECs[J]. Toxicol Appl Pharmacol, 2017, 323: 44-52. [11]Wang Y, Hall L M, Kujawa M, et al. Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K(ATP)/MAPK pathway[J]. Am J Physiol Cell Physiol, 2019, 317: 68-81. [12]Rabbani N, Thornalley PJ. Emerging glycation-based therapeutics-glyoxalase 1 inducers and glyoxalase 1 inhibitors[J]. Int J Mol Sci, 2022, 23:2453-2472. [13]Lee JH, Parveen A, Do MH, et al. Molecular mechani-sms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cells[J]. Cell Death Dis, 2020, 11: 403-417. [14]Li W, Chen Z, Yan M, et al. The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation[J]. J Neurochem, 2016, 136: 651-659. |