Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (4): 660-664.doi: 10.16352/j.issn.1001-6325.2023.04.0660

• Mini Reviews • Previous Articles     Next Articles

Research progress on the role of kallikrein 8 in neurological diseases

LIU Shiyu, LIU Yujian*   

  1. School of Kinesiology, the Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health,Shanghai University of Sport, Shanghai 200438, China
  • Received:2021-10-14 Revised:2022-06-02 Online:2023-04-05 Published:2023-04-03
  • Contact: *

Abstract: Kallikrein 8(KLK8) is closely related to the central nervous system and is involved in the pathological processes of many neurological diseases by altering inter-synaptic adhesion relationships and extracellular matrix molecules thereby modifying synaptic morphology and regulating synaptic plasticity. In this paper, we review the role and pathogenesis of KLK8 in neurological disorders such as dysthymic disorders, Alzheimer's disease, epilepsy, and multiple sclerosis with respect to its physiological properties. It is expected to provide a theoretical basis for the diagnosis and prognosis of neurological diseases and provide directions for the research of such diseases.

Key words: kallikrein 8, synaptic plasticity, dysthymic disorders, Alzheimer's disease

CLC Number: