Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 509-513.doi: 10.16352/j.issn.1001-6325.2023.03.509

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Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy

ZHANG Yixin1, CAI Shanjun1*, LI Zhili2, YU Weihong3, ZHANG Hua4*   

  1. 1. Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003;
    2. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;
    3. Department of Ophthalmology, Peking Union Medical College Hospital;
    4. College of Continuing Education, CAMS & PUMC, Beijing 100730, China
  • Received:2022-04-02 Revised:2022-10-17 Online:2023-03-05 Published:2023-02-27
  • Contact: *;

Abstract: Diabetic retinopathy (DR) is an immune-inflammatory disease and immunoglobulin G(IgG) N-glycosylation modifications are closely associated with DR. Among them, the modification of galactosylation, fucosylation, sialylation and bisecting N-acetylglucosamine of IgG changed has been proved to be predisposing factor to stimulate inflammation and related retinopathy.

Key words: diabetic retinopathy, immunoglobulin G, glycosylation modification

CLC Number: