Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (7): 1129-1133.doi: 10.16352/j.issn.1001-6325.2022.07.1129

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Research progress on the role of ferroptosis in Alzheimer's disease

XU Juan, LI Ye*   

  1. School of Medicine, Kunming University of Science and Technology, Kunming 650500, China
  • Received:2021-10-28 Revised:2022-05-07 Online:2022-07-05 Published:2022-06-29
  • Contact: *

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. The symptoms of progressive neuronal loss and death in AD, as well as the hyper-oxidative stress associated with abnormal brain iron levels, may be related to ferroptosis, a new way of cell death. Two characteristics of ferroptosis, iron homeostasis and lipid peroxidation, may potentially link ferroptosis to AD. The research on potential role of ferroptosis may provide new ideas for the treatment of AD.

Key words: Alzheimer's disease(AD), ferroptosis, iron homeostasis disorder, lipid peroxidation

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