Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 173-178.doi: 10.16352/j.issn.1001-6325.2022.01.034

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Immune microenvironment and immunotherapy of pituitary adenomas

GUO Xiao-peng, XING Bing*, MA Wen-bin   

  1. Department of Neurosurgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China
  • Received:2021-10-12 Revised:2021-11-22 Online:2022-01-05 Published:2022-01-05
  • Contact: *

Abstract: Pituitary adenomas (PAs) are the second most common primary central nervous system tumors. Although most PAs can be cured by surgical operation, medicine treatment or radiotherapy, some PAs may recur, invade adjacent structures or even metastasize to other organs after traditional treatments, so decreaseing patient overall survival and deteriorate their life quality. In recent years, studies on the immune microenvironment of brain tumors emerged, especially in the field of glioma, providing potential effective treatment targets for immunotherapy and setting the foundation for improving patient survival. However, previous studies have only conducted preliminary analyses on immune cells, immune molecules, and cytokines in the microenvironment of PAs. The research on immunotherapy of PAs with animal model and humans is only at an early phase.

Key words: pituitary adenoma, immune microenvironment, immunotherapy

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