Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 145-148.doi: 10.16352/j.issn.1001-6325.2022.01.020

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Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin*, LIU Yu-pu   

  1. Department of Human Anatomy,School of Basic Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China
  • Received:2020-11-27 Revised:2021-05-06 Online:2022-01-05 Published:2022-01-05
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Abstract: Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism

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