Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (11): 1522-1525.
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Abstract: Objective To predict potential regulators of γ- and β-globin gene. Methods The RNA-seq data of differential expression between γ- and β-globin were analysed to screen the differential expressed genes and IPA was used to explore the upstream regulators. Prediction of γ- and β-globin gene regulators was conducted by STRING database and Centiscape software. Results Known globin gene regulators such as BCL11A, NF-E2, YY1, GATA1 were predicted in the protein-protein interaction network. And 14 potential regulators were both predicted from two sets of data. Conclusion MAPK1, TNF, IFN etc predicted regulators may regulate γ- and β-globin gene expression. And it requires further molecular biology experiments to confirm.
Key words: transcriptomic, γ-globin, β-globin, regulator
CLC Number:
11-2652/R
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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2018/V38/I11/1522