Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (4): 553-556.
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Abstract: Mitochondrial fusion、fission and dynamic transformation between the two are commonly known as mitochondrial dynamics. Mitochondrial fusion-fission is related to a variety of biological functions of mitochondria, including regulation of energy metabolism, production of reactive oxygen species, m aintenance of Ca2+ homeostasis and influence of cellular death.It is reported that cardiac development、energy metabolism and ion homeostasis are closely related to the balance of mitochondrial fusion-fission.Mitochondrial fusion-fission disorders could cause myocardial cell dysfunction、damage and even the death of myocardial cells, which result in heart failure ultimately. Developing drugs aiming to reconstruct the balance of mitochondrial fusion-fission may provide new ideas and strategies for the treatment of chronic heart failure.
Key words: Key words: Mitochondria, Fusion, Fission, Heart failure
CLC Number:
R541.6
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2018/V38/I4/553