Abstract: Endotoxin tolerance is a protective mechanism of excessive inflammatory response. TLR4 signaling pathway plays critical roles in endotoxin tolerance. Epigenetics is a phenomenon that alters gene expression pattern without DNA sequence;it could modulates the process of endotoxin tolerance through microRNA, long non-coding RNA regulation and histone modification.

Key words: endotoxin tolerance, epigenetic regulation, microRNA, IncRNA, histone modification