Abstract: Under the testicular seminiferous tubule microenvironment control, spermatogonial stem cells (SSC) can only differentiate into sperms. Recent studies have shown that SSC may reprogram into pluripotent stem cells, or even directly reprogramming transdifferentiation into functional terminally differentiated cells under certain conditions in vitro. This potential of SSC makes it promise in the regenerative medicine and precise medicine application.

Key words: spermatogonial stem cell, conversion, transdifferentiation