Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (1): 117-120.
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Abstract: Acquired resistance to EGFR-TKI after a period of time has become a puzzle in clinic treatment. This review introduced the mechanism of acquired resistance to EGFR-TKI and focused on the recent discovered treatments after TKI resistance, including pan-HER TKI, EGFR-VEGFR double inhibition,C-MET inhibitor, PTEN activator and new drugs targeting EGFR mutation.
Key words: epidermal growth factor receptor- tyrosine kinase inhibitors, drug resistance, therapeutic strategies
CLC Number:
R730.53
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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2014/V34/I1/117