Association between the Angiotensin-Converting Enzyme Gene I/D polymorphism and Post-cerebral Infarction Depression

Abstract

Abstract: Abstract：Objective To explore the association between the angiotensin-converting enzyme（ACE）gene I/D polymorphism and post-cerebral infarction depression（PCID）．Methods The ACE gene I/D polymorphism was detected in a study of 664 cerebral infraction cases, 286 post-cerebral infarction depression cases and 378 control cases without depression after cerebral infarction were classified. The association of gene polymorphism and post-cerebral infarction depression was evaluated. Results The genotype frequencies of ACE gene I/I and I allete in the PCID group（0.388 and 0.549） were significantly higher than those in the control group （0.286 and 0.481）. Conclusions These results suggest that ACE gene I/I variant is significantly associated with post-cerebral infarction depression.

Key words: angiotensin-converting enzyme, gene polymorphism, post-cerebral infarction depression

References

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