Abstract: Objective To evaluate the effect of oral probiotics containing 4 strains of lactobacillus on the vaginal microbiota and adjuvant treatment effect of patients with vaginitis during pregnancy. Methods A total of 395 cases were included, 171 cases in the control group received 7 days of antibiotic treatment, and 224 cases in the combined treatment group. After the combined use of antibiotics and probiotics for 7 days, they continued to take 1 probiotic pill daily for the 28th day. The patients received a vaginal microecological examination and clinical evaluation at study entry and 28 days to compare the vaginal lactobacillus between the two groups. Results There was a statistical difference in the proportion of vaginal lactobacillus and the efficacy of treatment between the two groups of patients (P＜0.05). The effective rates in the combined treatment group and the control group were 90.2% and 86.0% respectively, and the cure rates were 30.4% and 19.3% respectively. Conclusions Oral probiotics containing lactobacillus strains can increase the proportion of vaginal lactobacillus in patients with vaginitis during pregnancy which significantly facilitated the clinical treatment of vaginitis during pregnancy.

Key words: oral probiotics, lactobacillus, pregnancy, vaginitis, vaginal microbiota