Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (4): 690-694.doi: 10.16352/j.issn.1001-6325.2023.04.0690

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Research progress on the role of HMGB1 signal pathway in bronchial asthma

SUN Ying1, YANG Zhian1, HE Yao1, YU Qin2*   

  1. 1. the First School of Clinical Medcine, Lanzhou University, Lanzhou 730000;
    2. Department of Respiratory, the First Hospital of Lanzhou University,Lanzhou 730000,China
  • Received:2021-12-31 Revised:2022-05-31 Online:2023-04-05 Published:2023-04-03
  • Contact: *

Abstract: High mobility group box 1 protein (HMGB1), as a ubiquitous nuclear protein, expresses in almost all cells. After activation and release, HMGB1 binds to its receptor and mediates pulmonary inflammatory response. HMGB1 signaling pathway is closely related to the occurrence and development of bronchial asthma. Related targeted drug therapy has been carried out in animal test and in clinical trials.

Key words: HMGB1, bronchial asthma, airway inflammation, airway remodeling

CLC Number: