Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 145-148.

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Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

  

  • Received:2020-11-27 Revised:2021-04-29 Online:2022-01-05 Published:2022-01-05
  • Supported by:
    Exosome mediated miR-21 transmission participates in electroacupuncture promoting the repair of sciatic nerve after injury in rats

Abstract: Schwann cells (SCs) have strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. In this review, we discuss the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism