Progress on the role of cardiac-specific microRNA in myocardial infarction

Abstract

Abstract: Cardiac-specific miRNAs, such as miR-1, miR-133, miR499 and miR208, are widely involved in cardiogenesis, physiology and pathology of heart. Cardiac-specific miRNAs are not only involved in cardiomyocyte differentiation in early cardiogenic stages and cardiomyocyte proliferation in the late cardiogenic stages, but also in cell damage or protection, fibrosis, and ventricular remodeling in myocardial infarction (MI) after birth. Meanwhile, cardiac-specific miRNAs can mobilize bone marrow stem cells into the peripheral blood, and promote heart repair and regeneration. In addition, circulating level of cardiac-specific miRNAs are significantly elevated after MI, which makes them to be a promising diagnostic marker for early diagnosis of acute MI.

Key words: cardiac-specific microRNAs, myocardial infarction, myocardial protection, tissue regeneration

CLC Number:

WANG Qiang-li, ZHAO Yue, GUO Hai-dong, WANG Ying. Progress on the role of cardiac-specific microRNA in myocardial infarction[J]. Basic & Clinical Medicine, 2021, 41(8): 1190-1194.

References

[1]Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing[J]. Cell, 2007, 129: 1401-1414.
[2]Guo Z, Maki M, Ding R, et al. Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues[J]. Sci Rep, 2014, 4: 5150. doi: 10.1038/srep05150.
[3]Ludwig N, Leidinger P, Becker K, et al. Distribution of miRNA expression across human tissues[J]. Nucleic Acids Res, 2016, 44: 3865-3877.
[4]Paoletti C, Divieto C, Tarricone G, et al. microRNA mediated direct reprogramming of human adult fibroblasts toward cardiac phenotype[J]. Front Bioeng Biotechnol, 2020, 8: 529. doi: 10.3389/fbioe.2020.00529.
[5]Cheng M, Yang J, Zhao X, et al. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells[J]. Nat Commun, 2019, 10: 959. doi: 10.1038/s41467-019-08895-7.
[6]García-Padilla C, Domínguez JN, Aránega AE, et al. Differential chamber-specific expression and regulation of long non-coding RNAs during cardiac development[J]. Biochim Biophys Acta Gene Regul Mech, 2019, 1862: 194435. doi: 10.1016/j.bbagrm.2019.194435.
[7]Gan J, Tang FMK, Su X, et al. microRNA-1 inhibits cardiomyocyte proliferation in mouse neonatal hearts by repressing CCND1 expression[J]. Ann Transl Med, 2019, 7: 455. doi: 10.21037/atm.2019.08.68.
[8]Tarhriz V, Eyvazi S, Musavi M, et al. Transient induc-tion of Cdk9 in the early stage of differentiation is critical for myogenesis[J]. J Cell Biochem,2019, 120: 18854-18861.
[9]Liu Y, Liang Y, Zhang JF, et al. microRNA-133 mediates cardiac diseases: mechanisms and clinical implications[J]. Exp Cell Res, 2017, 354: 65-70.
[10]Izarra A, Moscoso I, Cañón S, et al. miRNA-1 and miRNA-133a are involved in early commitment of pluripotent stem cells and demonstrate antagonistic roles in the regulation of cardiac differentiation[J]. J Tissue Eng Regen Med, 2017, 11: 787-799.
[11]Zhao X, Wang Y, Sun X. The functions of microRNA-208 in the heart[J]. Diabetes Res Clin Pract, 2020, 160: 108004. doi: 10.1016/j.diabres.2020.108004.
[12]Gonçalves TJM, Boutillon F, Lefebvre S, et al. Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation[J]. Sci Rep, 2019, 9:5878. doi: 10.1038/s41598-019-42296-6.
[13]Xu M, Chen X, Chen D, et al. MicroRNA-499-5p regulates skeletal myofiber specification via NFATc1/MEF2C pathway and Thrap1/MEF2C axis[J]. Life Sci, 2018, 215: 236-245.
[14]Agiannitopoulos K, Pavlopoulou P, Tsamis K, et al. Expression of miR-208b and miR-499 in greek patients with acute myocardial infarction[J]. In Vivo, 2018, 32: 313-318.
[15]Hu Y, Chen X, Li X, et al. microRNA-1 downregulation induced by carvedilol protects cardiomyocytes against apoptosis by targeting heat shock protein 60[J]. Mol Med Rep, 2019, 19: 3527-3536.
[16]Han Y, Cai Y, Lai X, et al. lncRNA RMRP prevents mitochondrial dysfunction and cardiomyocyte apoptosis via the miR-1-5p/hsp70 axis in LPS-induced sepsis mice[J]. Inflammation, 2020, 43:605-618.
[17]Xu J, Cao D, Zhang D, et al. microRNA-1 facilitates hypoxia-induced injury by targeting NOTCH3[J]. J Cell Biochem, 2020. doi: 10.1002/jcb.29663.
[18]Li W, Liu M, Zhao C, et al. miR-1/133 attenuates cardiomyocyte apoptosis and electrical remodeling in mice with viral myocarditis[J]. Cardiol J, 2020, 27: 285-294.
[19]Meng LD, Meng AC, Zhu Q, et al. Effect of microRNA-208a on mitochondrial apoptosis of cardiomyocytes of neonatal rats[J]. Asian Pac J Trop Med, 2015, 8: 747-751.
[20]Zhang S, Zhang R, Wu F, et al. microRNA-208a regulates H9C2 cells simulated ischemia-reperfusion myocardial injury via targeting CHD9 through Notch/NF-kappa B signal pathways[J]. Int Heart J, 2018, 59: 580-588.
[21]Shi Y, Han Y, Niu L, et al. miR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6[J]. Biotechnol Lett, 2019, 41: 837-847.
[22]Ajuyah P, Hill M, Ahadi A, et al. microRNA (miRNA)-to-miRNA regulation of programmed cell death 4 (PDCD4)[J]. Mol Cell Biol, 2019, 39: e00086-19. doi: 10.1128/MCB.00086-19.
[23]Peng Y, Song X, Zheng Y, et al. Circular RNA profiling reveals that circCOL3A1-859267 regulate type Ⅰ collagen expression in photoaged human dermal fibroblasts[J]. Biochem Biophys Res Commun, 2017, 486:277-284.
[24]Yu BT, Yu N, Wang Y, et al. Role of miR-133a in regulating TGF-β1 signaling pathway in myocardial fibrosis after acute myocardial infarction in rats[J]. Eur Rev Med Pharmacol Sci, 2019, 23: 8588-8597.
[25]Zhu Y, Zou C, Jia Y, et al. Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133[J]. Cell Cycle, 2020, 19:2622-2630.
[26]Rawal S, Nagesh PT, Coffey S, et al. Early dysregula-tion of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium[J]. Cardiovasc Diabetol, 2019, 18:13. doi: 10.1186/s12933-019-0814-4.
[27]Chen Y, Zhao Y, Chen W, et al. microRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction[J]. Stem Cell Res Ther, 2017, 8: 268. doi: 10.1186/s13287-017-0722-z.