Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (8): 1186-1189.

• Mini Reviews • Previous Articles     Next Articles

Research progress of HIF-1 mediated autophagy in cardiac diseases

ZHANG Liu-jie1, LI Jing2, WU Bo1*   

  1. 1. Department of Pathophysiology, School of Basic Medical Sciences, Harbin 150086;
    2. Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China
  • Received:2019-12-16 Revised:2020-03-26 Online:2021-08-05 Published:2021-07-21
  • Contact: *wubow2012@aliyun.com

Abstract: Hypoxia-inducible factor 1 (HIF-1) regulates the expression of target genes to keep the balance between oxygen supply and oxygen consumption, maintains oxygen homeostasis. HIF-1 regulates autophagy in the cardiovascular system, which involves the HIF target gene BNIP3.

Key words: hypoxia-inducible factor 1, hypoxia, autophagy, cardiac

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