Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (7): 982-987.

• Original Articles • Previous Articles     Next Articles

Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90

KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong*   

  1. Department of Pharmacology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China
  • Received:2021-04-14 Revised:2021-05-18 Online:2021-07-05 Published:2021-06-17
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Abstract: Objective To analyze the correlation between the expression of heat shock protein 90 (Hsp90) and the recognition of LPLTPLP (P7) on different tumor tissues and para-carcinoma tissues. Methods The expression of HSP90 and recognition effects of FITC-P7 in 48 cases of patients with 16 types of organ tumors and matched or mismatched marginal or adjacent tissues were analyzed by immunohistochemistry and immunofluorescence, respectively. Results Hsp90 was highly expressed in tumor tissues than para-carcinoma tissues. FITC-P7 showed a preferred recognition effect on tumor tissues in proportion to Hsp90 expression levels as determined by immunohistochemistry. There was moderate correlation in the two groups of data (r=0.5147,P<0.01). Conclusions The recognition of tumor tissues by P7 is positively related to the expression level of Hsp90, suggesting the targeting of P7 at Hsp90.

Key words: heat shock protein 90(Hsp90), polypeptide, correlation analysis

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