Research progress on novel molecules and new targets for the control of invasive fungi

Abstract

Abstract: At present, the drug treatment for invasive fungal infection is challenged by serious adverse effects and drug resistance. Therefore, the research and development of safe and effective new antifungal drugs is a great importance to support the clinical treatment of invasive fungal diseases. This article reviewed new targets of invasive fungi, and explores the underlying mechanisms of fungal biofilm formation, cell wall,key metabolic enzymes, mitochondria in the aspects of small molecule inhibitors and secondary metabolites, which may provide reference for the research and development of new drugs.

Key words: invasive fungi, target, small molecule inhibitors, molecular mechanism

CLC Number:

R735.1

GUO Xi, LAI Xin-xiu, YANG Mei-yan, LI Qiao-zhen, WANG Si-hang, SONG Zhang-yong. Research progress on novel molecules and new targets for the control of invasive fungi[J]. Basic & Clinical Medicine, 2021, 41(6): 904-908.

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