Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (3): 448-451.

• Mini Reviews • Previous Articles     Next Articles

Advances on the roles of tumor microenvironment in bone cancer pain

ZHOU Jia-hong, LI Min*   

  1. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China
  • Received:2020-08-07 Revised:2020-12-07 Online:2021-03-05 Published:2021-03-01
  • Contact: *liminanesth@aliyun.com

Abstract: Tumor microenvironment (TME) is the in vitro microenvironment in which tumors live. Cancer-induced bone pain(CIBP) is one of the most common symptoms of tumor bone metastasis. The mechanisms of bone cancer pain(BCP) are complex, and the tumor acidic microenvironment, the related ion channels and inflammatory mediators released by cancer, play a role in BCP.

Key words: tumor microenvironment, bone cancer pain, inflammatory mediators

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