Progress in molecular mechanism and targeted drugs of bone metastases in breast cancer

Abstract

Abstract: Breast cancer is the most common malignant tumor that threatens the health of women around the world, and bone is the site most prone to metastasis. The molecular mechanism concerned and targeted therapy against bone metastasis of breast cancer have become the current research hotspots. This article summarizes the key molecules involved in regulating bone metastasis of breast cancer. The important targeted therapy drugs are introduced and their efficacy is compared in two categories of those targeting at osteoclasts and those targeting at osteoblasts.

Key words: breast cancer bone metastasis, vicious cycle, signal molecule, therapeutic target

CLC Number:

R736.3

ZHENG Ya-nan, LI Mei, ZHAO Ji-yuan. Progress in molecular mechanism and targeted drugs of bone metastases in breast cancer[J]. Basic & Clinical Medicine, 2021, 41(3): 433-437.

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