Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (2): 257-261.

• Mini Reviews • Previous Articles     Next Articles

Advances in the application of zebrafish in the study of acute kidney injury

MA Tian-tian1,2, SHI Xiao-xiao1,2, CHEN Li-meng1,2*   

  1. 1. Department of Nephrology, 2. State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China
  • Received:2020-03-21 Revised:2020-05-07 Online:2021-02-05 Published:2021-01-19
  • Contact: *

Abstract: Acute kidney injury (AKI) is a common critical illness in clinic, characterized by a sudden and continuous decline in kidney function. zebrafish, as a vertebrate model organism, is highly similar to human being in terms of kidney morphology, physiology and function, and is an ideal animal model for the study of kidney disease, which makes up for the deficiency of mammalian model. This review briefly described the structure and function of zebrafish kidney, the modeling methods and its application in AKI research.

Key words: zebrafish, kidney disease, acute kidney injury, kidney regeneration

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