Research progress on mRNA methylation and diseases

Abstract

Abstract: mRNA methylation modification, including N⁶-methyladenosine (m⁶A), N⁵-methylcytidine (m⁵C) and N¹-methyladenosine (m¹A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA. “Writers” “erasers” “readers” participate in the dynamic and reversible biological process of mRNA methylation modification, which can lead to tumor, virus infection, metabolism diseases, heart or nervous system diseases, etc. when abnormalities occur in a certain link. At present, there are many methylation modification detection technologies, among which the most popular one is high-throughput sequencing.

Key words: mRNA methylation, writers, erasers, readers, diseases

CLC Number:

LI Ran, HAO Yan-lei. Research progress on mRNA methylation and diseases[J]. Basic & Clinical Medicine, 2021, 41(11): 1671-1679.

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